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As you know, semaglutide and the other GLP-1 medications mimic the hormone your body releases when you eat, which is the one that suppresses hunger pangs
Elevated insulin inhibits hormone-sensitive lipase, the enzyme responsible for breaking down stored triglycerides
Why Your Diet While on a GLP-1 Still Matters Semaglutide and Tirzepatide work by: Slowing gastric emptying Improving insulin sensitivity Reducing appetite But that doesnt mean you can eat anything and lose weight
For instance, other GLP-1 receptor agonists may have a different impact on gastric emptying or be associated with a lower incidence of heartburn
Retatrutides GIPR cAMP EC50 is roughly an order of magnitude lower than tirzepatides, so meaningful GIP signaling happens at a fraction of the dose
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